Endocrine Abstracts

Background: OPKO Biologics is a clinical-stage public company developing long-acting therapeutic proteins utilizing CTP technology. The technology involves fusion of the C-terminal peptide of human chorionic gonadotropin (hCG), which is highly O-glycosylated, to the target protein. CTP enabled the production of a long-acting human growth hormone (hGH) (MOD-4023), which supports a single weekly injection in growth hormone-deficient patients. MOD-4023 is manufactured as a non-vi...

Human GH is a member of a family of closely related hormones that include prolactin and placental lactogen. GH regulates a wide variety of physiological processes, including growth and differentiation of muscle, bone and cartilage cells. The use of GH for the treatment of children with impaired linear growth has been accepted as an important therapeutic modality for many years. In addition, beneficial effects of GH replacement therapy in hypopituitary adults are well establish...